Bronsted Acid-Catalyzed Three-Component Reaction of Anilines, α-Oxoaldehydes, and α-Angelicalactone for the Synthesis of Complex Pyrrolidones

被引：12

作者：

Huo, Congde ^{[1
]}

Yuan, Yong ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Ecoenvironm Related Polymer Mat, Lanzhou 730070, Gansu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 24期

基金：

中国国家自然科学基金;

关键词：

GLYCINE DERIVATIVES; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; COUPLING REACTION; TRANSITION-METAL; PERFECT SYNERGY; IONIC LIQUIDS; ESTERS; ALKYLATION; FLUORINE;

D O I：

10.1021/acs.joc.5b02354

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green and efficient three-component reaction of easily available anilines, alpha-oxoaldehydes, and alpha-arigelicalactone was developed for the synthesis of highly functionalized pyrrolidones using dilute sulfuric acid as the Catalyst. Products were obtained in good to high yields a room temperature and under solvent-free conditions. The reaction could also be performed on a multigram scale with the same efficiency.

引用

页码：12704 / 12710

页数：7

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