Analysis of HLA-G protein expression in leprosy

被引：1
|
作者：
da Silva, Camila Rodrigues [1 ]
Sampaio, Lucas Henrique Ferreira [2 ]
Costa, Mauricio Barcelos [1 ]
de Paula Carneiro Cysneiros, Maria Auxiliadora [1 ]
Sadissou, Ibrahim Abiodoun [3 ]
de Oliveira Rodrigues Castilho, Mirian Lane [1 ]
de Moraes, Jonathan Ballico [2 ]
Donadi, Eduardo Antonio [3 ]
Wastoswki, Isabela Jube [2 ,4 ]
机构：
[1] Univ Fed Goias UFG, Goiania, Go, Brazil
[2] Univ Estadual Goias UEG, Goiania, Go, Brazil
[3] Univ Sao Paulo, Ribeirao Preto, SP, Brazil
[4] Mol Immunol Lab UEG UnU Laranjeiras, Ave Prof Alfredo de Castro S-N, BR-74855130 Goiania, Go, Brazil
来源：
IMMUNOGENETICS | 2020年 / 72卷 / 05期
关键词：
HLA; HLA-G; Leprosy; Immune response;
D O I：
10.1007/s00251-020-01168-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The aim of this study was to evaluate the expression of human leukocyte antigen G (HLA-G) in leprosy. Biopsy and serum samples were collected from 18 patients presenting with leprosy and from healthy controls. Samples were analyzed using immunohistochemistry and ELISA techniques. HLA-G expression was observed in biopsy samples of all patients. The healthy control samples were consistently negative for HLA-G expression. Control plasma samples displayed significantly higher HLA-G expression than those from the patients (p < 0.01). These results are the first demonstration of the expression of HLA-G in leprosy.
引用
收藏
页码：333 / 337
页数：5
相关论文
共 50 条
  • [31] HLA-G Gene Variability Is Associated with Papillary Thyroid Carcinoma Morbidity and the HLA-G Protein Profile
    Bertol, Bruna C.
    Debortoli, Guilherme
    Dias, Fabricio C.
    de Araujo, Jessica N. G.
    Maia, Luana S. M.
    de Almeida, Bibiana S.
    de Figueiredo-Feitosa, Nathalie L.
    de Freitas, Luiz Carlos C.
    Castelli, Erick C.
    Mendes-Junior, Celso T.
    Silbiger, Vivian N.
    Maciel, Lea M. Z.
    Donadi, Eduardo A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (16)
  • [32] Expression of HLA-G in patients with hepatocellular carcinoma
    Wang, Yan
    Ye, Zhou
    Meng, Xue-Qin
    Zheng, Shu-Sen
    HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2011, 10 (02) : 158 - 163
  • [33] HLA-G Neo-Expression on Tumors
    Loustau, Maria
    Anna, Francois
    Drean, Raphaelle
    Lecomte, Martin
    Langlade-Demoyen, Pierre
    Caumartin, Julien
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [34] Expression of HLA-G in patients with hepatocellular carcinoma
    Yan Wang
    Key Laboratory of Combined Multi-organ Transplantation
    and Key Laboratory of Organ Transplantation Zhejiang Province
    Hepatobiliary&PancreaticDiseasesInternational, 2011, 10 (02) : 158 - 163
  • [35] Modulation of HLA-G expression in leukemia cells
    Polakova, K.
    Bandzuchova, E.
    Tirpakova, J.
    Kuba, D.
    Russ, G.
    TISSUE ANTIGENS, 2009, 74 (01): : 96 - 96
  • [36] Soluble HLA-G expression in celiac disease
    Torres, M. I.
    Lopez-Casado, M. A.
    Luque, J.
    Pena, J.
    Rios, A.
    TISSUE ANTIGENS, 2006, 68 (04): : 353 - 353
  • [37] HLA-G expression in primary breast cancer
    Ribeiro, Enilze M. S. F.
    Cavalcanti, Teresa Cristina S.
    Cavalcanti, Fernanda S.
    Cavalli, Iglenir J.
    Bicalho, Maria da Graca
    TISSUE ANTIGENS, 2010, 75 (05): : 615 - 615
  • [38] Heterogeneity of HLA-G gene transcription and protein expression in malignant melanoma biopsies
    Paul, P
    Cabestré, FA
    Le Gal, FA
    Khalil-Daher, I
    Le Danff, C
    Schmid, M
    Mercier, S
    Avril, MF
    Dausset, J
    Guillet, JG
    Carosella, ED
    CANCER RESEARCH, 1999, 59 (08) : 1954 - 1960
  • [39] Expression of HLA-G in the human corneal epithelium
    Oshima, M
    Higa, K
    Ishibashi, N
    Aiba, M
    Shimmura, S
    Shimazaki, J
    Tsubota, K
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 : U563 - U563
  • [40] HLA-G expression is a fundamental prerequisite to pregnancy
    Rizzo, Roberta
    Melchiorri, Loredana
    Stignani, Marina
    Baricordi, Olavio R.
    HUMAN IMMUNOLOGY, 2007, 68 (04) : 244 - 250
12345