Analysis of HLA-G protein expression in leprosy

被引：1
|
作者：
da Silva, Camila Rodrigues [1 ]
Sampaio, Lucas Henrique Ferreira [2 ]
Costa, Mauricio Barcelos [1 ]
de Paula Carneiro Cysneiros, Maria Auxiliadora [1 ]
Sadissou, Ibrahim Abiodoun [3 ]
de Oliveira Rodrigues Castilho, Mirian Lane [1 ]
de Moraes, Jonathan Ballico [2 ]
Donadi, Eduardo Antonio [3 ]
Wastoswki, Isabela Jube [2 ,4 ]
机构：
[1] Univ Fed Goias UFG, Goiania, Go, Brazil
[2] Univ Estadual Goias UEG, Goiania, Go, Brazil
[3] Univ Sao Paulo, Ribeirao Preto, SP, Brazil
[4] Mol Immunol Lab UEG UnU Laranjeiras, Ave Prof Alfredo de Castro S-N, BR-74855130 Goiania, Go, Brazil
来源：
IMMUNOGENETICS | 2020年 / 72卷 / 05期
关键词：
HLA; HLA-G; Leprosy; Immune response;
D O I：
10.1007/s00251-020-01168-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The aim of this study was to evaluate the expression of human leukocyte antigen G (HLA-G) in leprosy. Biopsy and serum samples were collected from 18 patients presenting with leprosy and from healthy controls. Samples were analyzed using immunohistochemistry and ELISA techniques. HLA-G expression was observed in biopsy samples of all patients. The healthy control samples were consistently negative for HLA-G expression. Control plasma samples displayed significantly higher HLA-G expression than those from the patients (p < 0.01). These results are the first demonstration of the expression of HLA-G in leprosy.
引用
收藏
页码：333 / 337
页数：5
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