Label-free detection of DNA hybridization based on EIS investigation of conducting properties of functionalized polythiophene matrix

被引：39
|
作者：
Gautier, C
Cougnon, C
Pilard, JF
Casse, N
机构：
[1] Univ Mainz, CNRS, UC03M, UMR 6011,LCOM Chim Polymeres, F-72085 Le Mans 9, France
[2] Univ Maine, Lab Biol & Genet Evolut, F-72085 Le Mans 9, France
来源：
JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2006年 / 587卷 / 02期
关键词：
DNA sensor; free-label detection; DNA-modified polythiophene; electrochemical impedance spectroscopy;
D O I：
10.1016/j.jelechem.2005.11.021
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A conducting polythiophene sensor for direct label-free DNA detection is investigated by electrochemical impedance spectroscopy (EIS) and by quartz crystal microbalance. The end-modified DNA probe is covalently immobilized by using a new anchorage function. The hybridization detection is studied by EIS experiments. An equivalent circuit is suggested and the variations of individual values of parameters deduced from impedance fits are connected to the change of conformation during the hybridization process. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：276 / 283
页数：8
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