Label-Free Detection of DNA Hybridization Using Surface Enhanced Raman Spectroscopy

被引：224
|
作者：
Barhoumi, Aoune [1 ]
Halas, Naomi J. [1 ,2 ,3 ]
机构：
[1] Rice Univ, Dept Chem, Houston, TX 77005 USA
[2] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA
[3] Rice Univ, Dept Bioengn, Houston, TX 77005 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 37期
关键词：
NANOPARTICLE PROBES; SCATTERING; 2-AMINOPURINE; MICROARRAYS; CHIPS;
D O I：
10.1021/ja105678z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The SERS spectrum of DNA is strongly dominated by the strong spectral feature of adenine at 736 cm(-1); the presence of adenine can serve as an endogenous marker for the label-free SERS-based detection of DNA hybridization when the probe DNA sequence is adenine-free. The substitution of 2-aminopurine for adenine on the probe DNA sequence enables the detection of a target sequence using SERS, upon hybridization of the target with the 2-AP-substituted probe DNA sequence.
引用
收藏
页码：12792 / 12793
页数：2
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