DNA reorientation on Au nanoparticles: label-free detection of hybridization by surface enhanced Raman spectroscopy

被引：50
|
作者：
Papadopoulou, Evanthia [1 ]
Bell, Steven E. J. [1 ]
机构：
[1] Queens Univ Belfast, Sch Chem & Chem Engn, Innovat Mol Mat Grp, Belfast BT9 5AG, Antrim, North Ireland
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 39期
关键词：
D O I：
10.1039/c1cc13705k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DNA sequences attached to Au nanoparticles via thiol linkers stand up from the surface, giving preferential enhancement of the adenine ring breathing SERS band. Non-specific binding via the nucleobases reorients the DNA, reducing this effect. This change in intensity on reorientation was utilised for label-free detection of hybridization of a molecular beacon.
引用
收藏
页码：10966 / 10968
页数：3
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