Synthesis of chromene-2-thiones and in vitro evaluation of their antifungal and antibacterial activities

被引：0

作者：

Devi, Nepram Sushuma ^{[1
]}

Singh, Thokchom Prasanta ^{[1
]}

Khumanthem, Nonibala ^{[2
]}

Singh, Okram Mukherjee ^{[1
]}

机构：

[1] Manipur Univ, Dept Chem, Imphal 795003, Manipur, India

[2] Manipur Univ, Dept Life Sci, Imphal 795003, Manipur, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2013年 / 52卷 / 09期

关键词：

beta-Oxodithioester; cupric chloride; coumarin; solvent free; antimicrobial activity; COUMARIN DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclocondensation of beta-oxodithioesters with substituted 2-hydroxy benzaldehydes in presence of copper(II)chloride as the catalyst yields 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones (87-95% yields). These reactions are carried out under solvent-free conditions. All the synthesized compounds have been evaluated for their antifungal and antibacterial activities using tube dilution technique. Only five compounds are found exhibiting good antifungal and antibacterial activities.

引用

页码：1224 / 1231

页数：8

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