Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives

被引：13

作者：

Xu, Wei ^{[1
]}

Zhu, Xiao-Rui ^{[1
]}

Qian, Peng-Cheng ^{[1
]}

Zhang, Xing-Guo ^{[1
]}

Deng, Chen-Liang ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

SYNLETT | 2016年 / 27卷 / 20期

基金：

中国国家自然科学基金;

关键词：

copper catalysis; tandem reactions; aminobenzamides; tertiary amines; quinazolinones; OXIDATIVE SYNTHESIS; O-AMINOBENZAMIDES; CASCADE; 4(3H)-QUINAZOLINONES; INHIBITORS; AMINATION; CHEMISTRY; ALCOHOLS; OXIDANT; POTENT;

D O I：

10.1055/s-0036-1588881

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines for the formation of quinazolinone derivatives. The strategy includes two steps (cyclization and coupling) performed in one pot. A number of substrates reacted well under standard conditions to give the corresponding quinazolinone derivatives in moderate to good yields.

引用

页码：2851 / 2857

页数：7

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