Copper-catalyzed synthesis of 2-aminobenzimidazoles from carbonimidoyl dichlorides and amines

被引：12
|
作者：
Yu, Hui [1 ]
Liu, Qiong [1 ]
Li, Yuzhe [1 ]
Ni, Chongzhi [1 ]
机构：
[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 39期
基金：
美国国家科学基金会;
关键词：
2-Aminobenzimidazole; Copper-catalyzed; O-Haloaryl carbonimidoyl dichloride; BIFUNCTIONAL ORGANOCATALYSTS; O-HALOANILINES; EFFICIENT; DERIVATIVES; GUANYLATION; GUANIDINES;
D O I：
10.1016/j.tetlet.2012.07.072
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new protocol for the synthesis of a variety of 2-aminobenzimidazole derivatives has been developed. O-haloaryl carbonimidoyl dichloride reacted with anilines to generate an o-haloaryl guanidine intermediate, which underwent copper catalyzed ring closure to afford 2-aminobenzimidazole derivative in moderate yields (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5253 / 5256
页数：4
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