(11R,11aS-trans)-11-ethylthio-2,3,5,10,11,11a-hexahydro-1H-pyrrolo-[2,1-c][1,4]benzodiazepin-5-one

被引：0

作者：

Kubicki, M

Szkaradzinska, MB

Codding, PW

机构：

[1] UNIV CALGARY,DEPT CHEM,CALGARY,AB T2N 1N4,CANADA

[2] UNIV CALGARY,DEPT PHARMACOL,CALGARY,AB T2N 1N4,CANADA

[3] UNIV CALGARY,DEPT THERAPEUT,CALGARY,AB T2N 1N4,CANADA

[4] UNIV VICTORIA,DEPT CHEM,VICTORIA,BC V8W 2Y2,CANADA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1997年 / 53卷

关键词：

D O I：

10.1107/S0108270197005581

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pyrrolo ring in the title compound, C14H18N2OS, exhibits a flattened envelope conformation, while the benzodiazepine ring exists as a twisted boat. The intermolecular N-H ... O hydrogen bonds form helical chains of molecules connected by a 4(3) screw axis. The structure is disordered: both the pyrrolo and the ethylthio fragments occupy two alternative positions, with site-occupancy factors of 0.55 (1) and 0.45 (1).

引用

页码：1288 / 1290

页数：3

共 50 条

[31] 3-Methyl-1H-pyrrolo[2,1-c][1,4]oxazin-1-one
Khan, Salman Tariq
Yu, Peng
Hua, Erbin
Ali, Syed Nawazish
Nisa, Mehrun
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O711 - U5818
[32] 3-Phenyl-1H-pyrrolo[2,1-c][1,4]oxazin-1-one
Khan, Salman Tariq
Yu, Peng
Chantrapromma, Suchada
Guo, Yong-En
Afza, Nighat
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1469 - U1924
[33] First Total Synthesis of (Z)-11-(2-oxopropylidene)-2,3,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(10H)-one
More, Satish S.
Shanmughapriya, D.
Lingam, Y.
Patel, N. B.
SYNTHETIC COMMUNICATIONS, 2009, 39 (11) : 2058 - 2066
[34] Preparation of 5,10,11,11a-tetrahydro-1H,3H-thiazolo[2,3-c]- and 5,10,11,11a-tetrahydro-1H,3H-thiazolo[4,3-c]-[1,4]benzodiazepines
Dyatkin, AB
Maryanoff, BE
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2002, 34 (06) : 652 - 655
[35] SYNTHESIS OF C-14-LABELLED 1-2-3-4-11-11-HEXACHLORO-1-4-5-8-9-10-HEXAHYDRO-1-4-ENDO, ENDO-5-8-DIENDOMETHYLENENAPHTHALENE (ISODRIN)
BROOKS, GT
CHEMISTRY & INDUSTRY, 1958, (07) : 194 - 194
[36] 5-fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985):: An orally active arginine vasopressin antagonist with selectivity for V2 receptors
Albright, JD
Reich, MF
Delos Santos, EG
Dusza, JP
Sum, FW
Venkatesan, AM
Coupet, J
Chan, PS
Ru, X
Mazandarani, H
Bailey, T
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (14) : 2442 - 2444
[37] Crystal, molecular and electronic structure of (5S, 11R, 11aS)-11-hydroxy-5-methyl-1,2,3,4,5,6,11,11a-octahydropyrido[1,2-b]isoquinolin-5-ium iodide
Sivy, Julius
Safar, Peter
Zuziova, Jozefina
ACTA CHIMICA SLOVACA, 2018, 11 (02): : 94 - 98
[38] SYNTHESIS OF 5H-IMIDAZO[2,1-C]PYRROLO[1,2-A][1,4]BENZODIAZEPINE
DUCEPPE, JS
GAUTHIER, J
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1984, 21 (06) : 1685 - 1687
[39] Synthesis of novel benzo[h][1,6]naphthyridines via a rearrangement of hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepines
Hinschberger, A
Fabis, F
Santos, JSD
Rault, S
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 40 (02) : 255 - 259
[40] 3,4,4A,5-TETRAHYDRO-[1,2,4]TRIAZINO[6,1-C][1,4]BENZOXAZINE, C10H11N3O
ORTOLEVA, E
PILATI, T
SIMONETTA, M
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1983, 39 (MAY) : 605 - 607

← 1 2 3 4 5 →