5-fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985):: An orally active arginine vasopressin antagonist with selectivity for V2 receptors

被引：140

作者：

Albright, JD ^{[1
]}

Reich, MF

Delos Santos, EG

Dusza, JP

Sum, FW

Venkatesan, AM

Coupet, J

Chan, PS

Ru, X

Mazandarani, H

Bailey, T

机构：

[1] Wyeth Ayerst Res, Pearl River, NY 10965 USA

[2] Wyeth Ayerst Res, Princeton, NJ 08543 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 14期

关键词：

D O I：

10.1021/jm980179c

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2442 / 2444

页数：3

共 49 条

[1] 5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4] benzodiazepine-10(11H)-YL carbonyl)-2-pyridinyl] benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists
Aranapakam, V
Albright, JD
Grosu, GT
Santos, EGD
Chan, PS
Coupet, J
Ru, X
Saunders, T
Mazandarani, H
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (13) : 1737 - 1740
[2] THIOANALOGS OF ANTITUMOR ANTIBIOTICS .1. SYNTHESIS OF 7,8-DISUBSTITUTED 5,11-DIOXO-1,2,3,11A-TETRAHYDRO-5H,11H-PYRROLO(2,1-C)(1,4)BENZOTHIAZEPINE AND 5-OXO-2,3,11,11A-TETRAHYDRO-1H,5H-PYRROLO[2,1-C][1,4]BENZOTHIAZEPINE
NACCI, V
GAROFALO, A
ANZINI, M
FARMACO, 1989, 44 (04): : 423 - 433
[3] PYRROL(1,4)BENZODIAZEPIN STRUCTURES .1. SYNTHESIS OF 5,11-DIKETO-1,10,11, 11A-TETRAHYDRO-5H-PYRROLO[2,1-C]-[1,4] BENZODIAZEPINE
DEMARTINO, G
MASSA, S
CORELLI, F
FARMACO-EDIZIONE SCIENTIFICA, 1978, 33 (08): : 604 - 611
[4] PYRROLO[1,4]BENZODIAZEPINES .4. SYNTHESIS OF E-5,11-DIOXO-11A-ETHOXYCARBONYL-2-ETHYLIDENE-1,2,3,10,11,11A-HEXAHYDRO-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE AND Z-5,11-DIOXO-11A-ETHOXYCARBONYL-2-ETHYLIDENE-1,2,3,10,11,11A-HEXAHYDRO-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE
DECAPRARIIS, P
DEMARTINO, G
ABIGNENTE, E
AVARA, P
MAYOL, L
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (04) : 1023 - 1027
[5] PYRROLO[1,4]BENZODIAZEPINES .3. SYNTHESIS OF 5,11-DIOXO-1,10,11,11A-TETRAHYDRO-2-VINYL-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE
MASSA, S
DEMARTINO, G
CORELLI, F
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1982, 19 (06) : 1497 - 1499
[6] (11R,11aS-trans)-11-ethylthio-2,3,5,10,11,11a-hexahydro-1H-pyrrolo-[2,1-c][1,4]benzodiazepin-5-one
Kubicki, M
Szkaradzinska, MB
Codding, PW
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1997, 53 : 1288 - 1290
[7] POLYCONDENSED HETEROCYCLES .3. SYNTHESIS OF 5,11-DIOXO-1,2,3,11A-TETRAHYDRO-5H,11H-PYRROLO AND 5-OXO-2,3,11,11A-TETRAHYDRO-1H,5H-PYRROLO[2,1-C][1,4]BENZOTHIAZEPINE
NACCI, V
GAROFALO, A
ANZINI, M
CAMPIANI, G
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1988, 25 (03) : 1007 - 1013
[8] DERIVATIVES OF 11-(1-PIPERAZINYL)-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE AS CENTRAL NERVOUS-SYSTEM AGENTS
WRIGHT, WB
GREENBLATT, EN
DAY, IP
QUINONES, NQ
HARDY, RA
JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (04) : 462 - 465
[9] (4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators
Venkatesan, AM
Grosu, GT
Failli, AA
Chan, PS
Coupet, J
Saunders, T
Mazandarani, H
Ru, X
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (22) : 5003 - 5006
[10] (S)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione
Cheng, Mao-Sheng
Ma, Chao
Liu, Jing-Hong
Sha, Yu
Wang, Qing-He
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O4605 - U4107

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