(11R,11aS-trans)-11-ethylthio-2,3,5,10,11,11a-hexahydro-1H-pyrrolo-[2,1-c][1,4]benzodiazepin-5-one

被引：0
|
作者：
Kubicki, M
Szkaradzinska, MB
Codding, PW
机构：
[1] UNIV CALGARY,DEPT CHEM,CALGARY,AB T2N 1N4,CANADA
[2] UNIV CALGARY,DEPT PHARMACOL,CALGARY,AB T2N 1N4,CANADA
[3] UNIV CALGARY,DEPT THERAPEUT,CALGARY,AB T2N 1N4,CANADA
[4] UNIV VICTORIA,DEPT CHEM,VICTORIA,BC V8W 2Y2,CANADA
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1997年 / 53卷
关键词：
D O I：
10.1107/S0108270197005581
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The pyrrolo ring in the title compound, C14H18N2OS, exhibits a flattened envelope conformation, while the benzodiazepine ring exists as a twisted boat. The intermolecular N-H ... O hydrogen bonds form helical chains of molecules connected by a 4(3) screw axis. The structure is disordered: both the pyrrolo and the ethylthio fragments occupy two alternative positions, with site-occupancy factors of 0.55 (1) and 0.45 (1).
引用
收藏
页码：1288 / 1290
页数：3
相关论文
共 50 条
  • [21] DNA-binding properties of pyrrolo[2,1-c][1,4]-benzodiazepine N10-C11 amidines
    Foloppe, MP
    Rault, S
    Thurston, DE
    Jenkins, TC
    Robba, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (05) : 407 - 410
  • [22] DERIVATIVES OF 11-(1-PIPERAZINYL)-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE AS CENTRAL NERVOUS-SYSTEM AGENTS
    WRIGHT, WB
    GREENBLATT, EN
    DAY, IP
    QUINONES, NQ
    HARDY, RA
    JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (04) : 462 - 465
  • [23] (11R, 11aS)-11-hydroxy-1,5,11,11a-tetrahydro-1-benzothieno[2,3-f]indolizin-3(2H)-one
    Svorc, Lubomir
    Vrabel, Viktor
    Kozisek, Jozef
    Marchalin, Stefan
    Safar, Peter
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1164 - U2958
  • [24] Synthesis of 11-aryl-5H-imidazo[2,1-c][1,4]benzodiazepines and their benzodiazepine and A1 adenosine binding activity
    Castellano, S
    Zorzin, L
    Florio, C
    Frausin, F
    Stefancich, G
    FARMACO, 2001, 56 (10): : 771 - 778
  • [25] Design and Synthesis of 11H-Xantheno[2,1-c][1,2,5]Selenadiazol-11-One Derivatives as Potent Antimicrobial and Antitubercular Agents
    Bowroju, Suresh Kuarm
    Marumamula, Hanumaiah
    Bavanthula, Rajitha
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2021, 47 (02) : 593 - 600
  • [26] Design and Synthesis of 11H-Xantheno[2,1-c][1,2,5]Selenadiazol-11-One Derivatives as Potent Antimicrobial and Antitubercular Agents
    Suresh Kuarm Bowroju
    Hanumaiah Marumamula
    Rajitha Bavanthula
    Russian Journal of Bioorganic Chemistry, 2021, 47 : 593 - 600
  • [27] Efficient Synthesis of Naturally Occurring Skeleton 5-7-6 Tricyclic Pyrrolo[2,1-c][1,4]benzodiazepin-5-one and Its Derivatives via Cationic π-Cyclization
    Sharma, Sudhir K.
    Mandadapu, Anil K.
    Kumaresan, K.
    Arora, Ashish
    Gauniyal, Harsh M.
    Kundu, Bijoy
    SYNTHESIS-STUTTGART, 2010, (23): : 4087 - 4095
  • [28] RESEARCH ON SUBSTANCES WITH ANTIBLASTIC ACTIVITY .63. ANTHRAMYCIN AND ANALOGOUS COMPOUNDS .10. SYNTHESIS OF DERIVATIVES OF 11-PHENYL-5H-PYRROLO[2,1-C][1,4]BENZODIAZEPINE
    PORRETTA, GC
    SCICCHITANO, G
    FILACCHIONI, G
    SCALZO, M
    ARTICO, M
    FARMACO-EDIZIONE SCIENTIFICA, 1979, 34 (10): : 914 - 922
  • [29] Novel routes to 1,2,3,4-tetrahydropyrrolo[1,2-α]pyrazines and 5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-α]pyrrolo[2,1-c]pyrazines
    Katritzky, AR
    Jain, R
    Xu, YJ
    Steel, PJ
    JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (23): : 8220 - 8223
  • [30] trans-1-ethyl-4,4,10-trimethyl-2-tosyl-1,2,3,3a,4,11b-hexahydro-11H-pyrrolo[3,4-c]pyrano[5,6-c]quinolin-11-one
    Chinnakali, K.
    Sudha, D.
    Jayagobi, M.
    Raghunathan, R.
    Fun, Hoong-Kun
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O4650 - U4513
12345