Synthesis and biological activity of S-containing betulin derivatives

被引:11
|
作者
Tolmacheva, IA [1 ]
Shelepen'kina, LN [1 ]
Vikharev, YB [1 ]
Anikina, LV [1 ]
Grishko, VV [1 ]
Tolstikov, AG [1 ]
机构
[1] Russian Acad Sci, Urals Div, Inst Tech Chem, Perm 614990, Russia
关键词
triterpenoids; betulin; sulfides; sulfoxides; anti-inflammatory activity;
D O I
10.1007/s10600-006-0015-8
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
S-Containing derivatives of the natural triterpenoid betulin were synthesized. It has been found that the 30-thio- and 30-sulfinylbenzinfidazole derivatives of betulin exhibit anti-inflammatory activity comparable to that of sodium diclofenac
引用
收藏
页码:701 / 705
页数:5
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