Determination of Clonidine by Potentiometry Using PVC Membrane Electrode

被引：0
|
作者：
Ganjali, Mohammad Reza [1 ,2 ]
Karimi, Anahita [1 ]
Shahtaheri, Sayed Jamaleddin [3 ]
Norouzi, Parviz [1 ,2 ]
机构：
[1] Univ Tehran, Ctr Excellence Electrochem, Tehran, Iran
[2] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Tehran, Iran
[3] Univ Tehran Med Sci, Sch Publ Hlth, Dept Occupat Hlth, Environm Res Ctr, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2013年 / 8卷 / 02期
关键词：
Clonidine; Potentiometric Sensor; PVC membrane Electrode; Ion-Pair; COMPOSITE CARBON-PASTE; ION-SELECTIVE ELECTRODE; PHARMACEUTICAL FORMULATION; LANTHANIDE RECOGNITION; QUANTITATIVE-ANALYSIS; ANION RECOGNITION; SENSING MATERIAL; SENSOR; HYDROCHLORIDE; CONSTRUCTION;
D O I：
暂无
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
PVC membrane potentiometric sensor was made for determination of Clonidine in pharmaceutical formulations. The electrode respond based on ion-exchange mechanism. The ion-pair used as a sensing element in PVC membrane composition was synthesized by interaction of Clonidine hydrochloride and tetraphenyl borate. The best PVC membrane sensor response was obtained by a membrane composition of 30% PVC, 62% DBP, 6% ion-pair and 2% ionic liquid. The proposed method was successfully applied in determination of Clonidine in some formulations. The proposed sensor showed a linear dynamic range between 7.0x10(-6)-1.0x10(-2) M of Clonidine with a Nernstian slope of (58.3+/-0.4) mV decade(-1) and a detection limit of 6.5x10(-6) M. The proposed electrode displayed fast response time about 10 s, and lifetime of about six weeks without any significant change in its performance.
引用
收藏
页码：1999 / 2008
页数：10
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