Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.

被引：19

作者：

Chen, Tsung-Hung ^{[1
,2
]}

Lu, Mei-Chin ^{[1
,2
]}

Chang, Yu-Chia ^{[2
,3
,4
]}

Su, Yin-Di ^{[2
,5
,6
]}

Chen, Yu-Hsin ^{[2
,7
,8
]}

Lin, Nai-Cheng ^{[2
]}

Fang, Lee-Shing ^{[9
]}

Wu, Yang-Chang ^{[10
,11
,12
]}

Sung, Ping-Jyun ^{[1
,2
,11
,13
]}

机构：

[1] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan

[4] Acad Sinica, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[6] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Div Marine Biotechnol, Kaohsiung 804, Taiwan

[7] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan

[8] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan

[9] Cheng Shiu Univ, Dept Sport Hlth & Leisure, Kaohsiung 833, Taiwan

[10] China Med Univ, Coll Pharm, Sch Pharm, Taichung 404, Taiwan

[11] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[12] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[13] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

MARINE DRUGS | 2013年 / 11卷 / 11期

关键词：

eunicellin; Cladiella; cladieunicellin; litophynin; cytotoxicity; TUMOR-CELL-LINES; 2,11-CYCLIZED CEMBRANOIDS; AUSTRALIS; HIRSUTA; KREMPFI; GROWTH; ASSAY;

D O I：

10.3390/md11114585

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells.

引用

页码：4585 / 4593

页数：9

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