New 6-Hydroxyeunicellins from a Soft Coral Cladiella sp.

被引：18

作者：

Chen, Yung-Husan ^{[2
]}

Hwang, Tsong-Long ^{[3
]}

Su, Yin-Di ^{[2
,4
]}

Chang, Yu-Chia ^{[2
,6
,7
]}

Chen, Yu-Hsin ^{[2
,8
,9
]}

Hong, Pei-Han ^{[2
,10
]}

Hu, Li-Chung ^{[2
,10
]}

Yen, Wei-Hsuan ^{[2
,10
]}

Hsu, Hsin-Yin ^{[1
,2
]}

Huang, Shu-Jung ^{[1
,2
]}

Kuo, Yueh-Hsiung ^{[1
,11
]}

Sung, Ping-Jyun ^{[2
,4
,5
,8
,9
,10
]}

机构：

[1] China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource, Taichung 404, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Div Marine Biotechnol, Kaohsiung 804, Taiwan

[6] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan

[7] Acad Sinica, Kaohsiung 804, Taiwan

[8] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan

[9] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan

[10] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[11] China Med Univ, Coll Pharm, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2012年 / 60卷 / 01期

关键词：

cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase; EUNICELLIN-BASED DITERPENOIDS; A-E;

D O I：

10.1248/cpb.60.160

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

引用

页码：160 / 163

页数：4

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