New 6-Hydroxyeunicellins from a Soft Coral Cladiella sp.

被引：18
|
作者：
Chen, Yung-Husan [2 ]
Hwang, Tsong-Long [3 ]
Su, Yin-Di [2 ,4 ]
Chang, Yu-Chia [2 ,6 ,7 ]
Chen, Yu-Hsin [2 ,8 ,9 ]
Hong, Pei-Han [2 ,10 ]
Hu, Li-Chung [2 ,10 ]
Yen, Wei-Hsuan [2 ,10 ]
Hsu, Hsin-Yin [1 ,2 ]
Huang, Shu-Jung [1 ,2 ]
Kuo, Yueh-Hsiung [1 ,11 ]
Sung, Ping-Jyun [2 ,4 ,5 ,8 ,9 ,10 ]
机构：
[1] China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource, Taichung 404, Taiwan
[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan
[3] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan
[4] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Div Marine Biotechnol, Kaohsiung 804, Taiwan
[6] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan
[7] Acad Sinica, Kaohsiung 804, Taiwan
[8] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan
[9] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan
[10] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan
[11] China Med Univ, Coll Pharm, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2012年 / 60卷 / 01期
关键词：
cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase; EUNICELLIN-BASED DITERPENOIDS; A-E;
D O I：
10.1248/cpb.60.160
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
引用
收藏
页码：160 / 163
页数：4
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