Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.

被引：19

作者：

Chen, Tsung-Hung ^{[1
,2
]}

Lu, Mei-Chin ^{[1
,2
]}

Chang, Yu-Chia ^{[2
,3
,4
]}

Su, Yin-Di ^{[2
,5
,6
]}

Chen, Yu-Hsin ^{[2
,7
,8
]}

Lin, Nai-Cheng ^{[2
]}

Fang, Lee-Shing ^{[9
]}

Wu, Yang-Chang ^{[10
,11
,12
]}

Sung, Ping-Jyun ^{[1
,2
,11
,13
]}

机构：

[1] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 804, Taiwan

[4] Acad Sinica, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[6] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Div Marine Biotechnol, Kaohsiung 804, Taiwan

[7] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan

[8] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan

[9] Cheng Shiu Univ, Dept Sport Hlth & Leisure, Kaohsiung 833, Taiwan

[10] China Med Univ, Coll Pharm, Sch Pharm, Taichung 404, Taiwan

[11] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[12] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

[13] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

MARINE DRUGS | 2013年 / 11卷 / 11期

关键词：

eunicellin; Cladiella; cladieunicellin; litophynin; cytotoxicity; TUMOR-CELL-LINES; 2,11-CYCLIZED CEMBRANOIDS; AUSTRALIS; HIRSUTA; KREMPFI; GROWTH; ASSAY;

D O I：

10.3390/md11114585

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related analogues. Eunicellin 1 exhibited significant cytotoxicity toward the DLD-1 human colorectal adenocarcinoma cells.

引用

页码：4585 / 4593

页数：9

共 50 条

[21] Eunicellin-Based Diterpenoids from the Formosan Soft Coral Klyxum molle with Inhibitory Activity on Superoxide Generation and Elastase Release by Neutrophils
Lin, Ming-Chang
Chen, Bo-Wei
Huang, Chiung-Yao
Dai, Chang-Feng
Hwang, Tsong-Long
Sheu, Jyh-Horng
JOURNAL OF NATURAL PRODUCTS, 2013, 76 (09): : 1661 - 1667
[22] Simplexins A-I, Eunicellin-Based Diterpenoids from the Soft Coral Klyxum simplex
Wu, Shwu-Li
Su, Jui-Hsin
Wen, Zhi-Hong
Hsu, Chi-Hsin
Chen, Bo-Wei
Dai, Chang-Feng
Kuo, Yao-Haur
Sheu, Jyh-Horng
JOURNAL OF NATURAL PRODUCTS, 2009, 72 (06): : 994 - 1000
[23] Cladieunicellin T, a New Eunicellin-based Diterpenoid Produced by the Octocoral Cladiella sp
Zhang, Zhi-Jun
Peng, Bo-Rong
Hu, Chiung-Chih
Lin, Nai-Cheng
Yao, Jia-Wen
Lu, Mei-Chin
Wen, Zhi-Hong
Wu, Yang-Chang
Sung, Ping-Jyun
NATURAL PRODUCT COMMUNICATIONS, 2019, 14 (01) : 101 - 102
[24] Coniferains A and B, new eunicellin-based diterpenoids from the octocoral Cladiella (Tixier-Durivault, 1943)
Zeng, Jhao-Syuan
Tseng, Chung-Chih
Tsai, Yu-Chi
Chen, Shun-Hua
Chen, Po-Jen
Chen, Nan-Fu
Wen, Zhi-Hong
Hwang, Tsong-Long
Sung, Ping-Jyun
PHYTOCHEMISTRY LETTERS, 2022, 49 : 88 - 92
[25] Pachycladins A-E, Prostate Cancer Invasion and Migration Inhibitory Eunicellin-Based Diterpenoids from the Red Sea Soft Coral Cladiella pachyclados
Hassan, Hossam M.
Khanfar, Mohammad A.
Elnagar, Ahmed Y.
Mohammed, Rabab
Shaala, Lamiaa A.
Youssef, Diaa T. A.
Hifnawy, Mohamed S.
El Sayed, Khalid A.
JOURNAL OF NATURAL PRODUCTS, 2010, 73 (05): : 848 - 853
[26] Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex
Chen, Bo-Wei
Chao, Chih-Hua
Su, Jui-Hsin
Wen, Zhi-Hong
Sung, Ping-Jyun
Sheu, Jyh-Horng
ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (10) : 2363 - 2366
[27] Polyoxygenated diterpenoids of the eunicellin-type from the Chinese soft coral Cladiella krempfi
Cai, You-Sheng
Yao, Li-Gong
Di Pascale, Antonio
Irace, Carlo
Mollo, Ernesto
Taglialatela-Scafati, Orazio
Guo, Yue-Wei
TETRAHEDRON, 2013, 69 (09) : 2214 - 2219
[28] Klymollins T-X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle
Chang, Fang-Yu
Hsu, Fang-Jung
Tai, Chi-Jen
Wei, Wen-Chi
Yang, Ning-Sun
Sheu, Jyh-Horng
MARINE DRUGS, 2014, 12 (05): : 3060 - 3071
[29] Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.
Chen, Yung-Husan
Tai, Chia-Ying
Hwang, Tsong-Long
Weng, Ching-Feng
Li, Jan-Jung
Fang, Lee-Shing
Wang, Wei-Hsien
Wu, Yang-Chang
Sung, Ping-Jyun
MARINE DRUGS, 2010, 8 (12): : 2936 - 2945
[30] New hemiketal steroid from the soft coral Cladiella sp.
Zhang, GW
Ma, XQ
Kurihara, H
Zhang, CX
Yao, XS
Su, JY
Zeng, LM
ORGANIC LETTERS, 2005, 7 (06) : 991 - 994

← 1 2 3 4 5 →