Label-Free Pathogen Detection with Sensor Chips Assembled from Peptide Nanotubes

被引：58
|
作者：
de la Rica, Roberto [1 ]
Mendoza, Ernest [2 ]
Lechuga, Laura M. [2 ]
Matsui, Hiroshi [1 ]
机构：
[1] CUNY Hunter Coll, Dept Chem & Biochem, New York, NY 10065 USA
[2] ETSE, CSIC ICN, Res Ctr Nanosci & Nanotechnol CIN2, Nanobiosensors & Mol Nanobiophys Grp, Barcelona 08193, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 50期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
bionanotechnology; peptide nanotubes; self-assembly; sensors; viruses;
D O I：
10.1002/anie.200804299
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A robust viral sensor was developed by bridging a pair of gold electrodes with antibody-coated peptide nanotubes. The nanotubes concentrated the target virus on their surface by molecular recognition between the antibody and the virus (see picture). The nanotubes fit perfectly within the electric field line distribution to enable the extremely sensitive impedimetric detection of viral particles. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9752 / 9755
页数：4
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