Bio-assay Guided Isolation of α-Glucosidase Inhibitory Constituents from Eclipta alba

被引：1
|
作者：
Kumar, Deepak [1 ]
Gaonkar, Raghuvir H. [1 ]
Ghosh, Rina [2 ]
Pal, Bikas C. [1 ]
机构：
[1] NIPER, Kolkata 700032, India
[2] Jadavpur Univ, Dept Chem, Kolkata 700032, India
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 08期
关键词：
Eclipta alba; alpha-Glucosidase; Eclalbasaponins; Diabetes mellitus; PROSTRATA;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Eclipto alba (L.) Hassk is used traditionally in diabetes mellitus in India and the plant extract is reported to possess anti-diabetic activity. A bioactivity-guided isolation approach based on a-glucosidase inhibition was used to identify the constituents contributing towards the inhibition of the enzyme and probably contributing towards its anti-diabetic activity. Four echinocystic acid glycosides were thus isolated, of which eclalbasaponin VI, isolated from the n-butanol fraction, was found to be the most potent (IC50 54.2 +/- 1.3 mu M). The compound is an uncompetitive type of inhibitor with Ki 26.1 mu M. A quantitative estimation of the constituents was established using RP-HPLC.
引用
收藏
页码：989 / 990
页数：2
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