Bio-assay Guided Isolation of α-Glucosidase Inhibitory Constituents from Eclipta alba

被引：1

作者：

Kumar, Deepak ^{[1
]}

Gaonkar, Raghuvir H. ^{[1
]}

Ghosh, Rina ^{[2
]}

Pal, Bikas C. ^{[1
]}

机构：

[1] NIPER, Kolkata 700032, India

[2] Jadavpur Univ, Dept Chem, Kolkata 700032, India

来源：

NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 08期

关键词：

Eclipta alba; alpha-Glucosidase; Eclalbasaponins; Diabetes mellitus; PROSTRATA;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eclipto alba (L.) Hassk is used traditionally in diabetes mellitus in India and the plant extract is reported to possess anti-diabetic activity. A bioactivity-guided isolation approach based on a-glucosidase inhibition was used to identify the constituents contributing towards the inhibition of the enzyme and probably contributing towards its anti-diabetic activity. Four echinocystic acid glycosides were thus isolated, of which eclalbasaponin VI, isolated from the n-butanol fraction, was found to be the most potent (IC50 54.2 +/- 1.3 mu M). The compound is an uncompetitive type of inhibitor with Ki 26.1 mu M. A quantitative estimation of the constituents was established using RP-HPLC.

引用

页码：989 / 990

页数：2

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