Measurement of glucose concentration by fiber-optic surface plasmon resonance sensor

A measurement method of glucose concentration based on fiber-optic surface plasmon resonance (FO-SPR) is proposed to achieve online, real-time detection of human blood glucose concentration. The end-reflection structure of FO-SPR sensor was simulated and the impact of different parameters on sensor performance was analyzed. Then the FO-SPR sensor was manufactured according to the optimized parameters. A glucose concentration measurement system with SPR sensor was set up. Glucose solutions with different concentrations were measured and the experiment results showed that the correlation coefficient of fitting curve between the glucose concentration and resonance wavelength was above 0.95 at the human blood glucose range of 0 similar to 200mg/dL. The measurement repeatability was also proved to be able to meet the requirements of blood glucose concentration detection in clinics.