Discovery of a novel small molecule inhibitor of the YAP1/TAZ-TEAD transcriptional complex

被引:0
|
作者
Moure, Casey J. [1 ]
Sondey, Christopher [1 ]
Cheng, Mangeng [1 ]
Mansueto, My [1 ]
Fernandez, Rafael [1 ]
Schneider, Sebastian E. [1 ]
Ramirez, Julia V. [1 ]
Long, Brian [1 ]
DiMauro, Erin [1 ]
Vara, Brandon [1 ]
Yeung, Charles [1 ]
Achab, Abe [1 ]
Lim, Jongwon [1 ]
Kim, Ronald [1 ]
Zarate, Cayetana [1 ]
Bennett, Jonathan [1 ]
Palte, Rachel [1 ]
Foti, Robert [1 ]
Simov, Vladimir [1 ]
Barry, Evan [1 ]
机构
[1] Merck Sharp & Dohme Ltd, Boston, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3938
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Targeting transcriptional co-activators YAP1/TAZ in fusion-positive rhabdomyosarcoma demonstrates a novel strategy in ablating fusion-driven sarcoma transcriptional programing
    Pecoraro, Adam F.
    Rashid, Tooba
    Burgess, Breanne A.
    Linardic, Corinne M.
    Deel, Michael D.
    CANCER RESEARCH, 2022, 82 (12)
  • [42] YEAST YAP1 ENCODES A NOVEL FORM OF THE JUN FAMILY OF TRANSCRIPTIONAL ACTIVATOR PROTEINS
    MOYEROWLEY, WS
    HARSHMAN, KD
    PARKER, CS
    GENES & DEVELOPMENT, 1989, 3 (03) : 283 - 292
  • [43] Synergistic effects of dual inhibition of YAP1 and TAZ in non-small cell lung cancer cells
    Shum, Elaine
    Liu, Huijie
    Zhu, Liang
    Perez-Soler, Roman
    Halmos, Balazs
    Cheng, Haiying
    CANCER RESEARCH, 2017, 77
  • [44] Genome-wide CRISPR/Cas9 screen for the identification of novel YAP1/TAZ modulators
    Naujoks, Jan
    Potze, Lisette
    Anurin, Anna
    Kuehnlenz, Julia
    Lesche, Ralf
    Kamburov, Atanas
    Nevedomskaya, Ekaterina
    Steffen, Andreas
    Lange, Martin
    Nicke, Barbara
    CANCER RESEARCH, 2019, 79 (13)
  • [45] Serum Inter-α-inhibitor Activates the Yes Tyrosine Kinase and YAP/TEAD Transcriptional Complex in Mouse Embryonic Stem Cells
    Pijuan-Galito, Sara
    Tamm, Christoffer
    Anneren, Cecilia
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (48) : 33492 - 33502
  • [46] Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor
    Mognol, Giuliana P.
    Gonzalez-Avalos, Edahi
    Ghosh, Srimoyee
    Spreafico, Roberto
    Gudlur, Aparna
    Rao, Anjana
    Damoiseaux, Robert
    Hogan, Patrick G.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (20) : 9959 - 9968
  • [47] Genome-wide CRISPR/Cas9 screens for the identification of novel YAP1/TAZ modulators.
    Naujoks, Jan
    Potze, Lisette
    Kuehnlenz, Julia
    Kamburov, Atanas
    Nevedomskaya, Ekaterina
    Steffen, Andreas
    Luther, Claudia
    Anurin, Anna
    Buttgereit, Anne
    Prechtl, Stefan
    Bader, Benjamin
    Lesche, Ralf
    Staller, Peter
    Lange, Martin
    Nicke, Barbara
    MOLECULAR CANCER RESEARCH, 2020, 18 (08) : 36 - 36
  • [48] Leveraging Advanced In Silico Techniques in Early Drug Discovery: A Study of Potent Small-Molecule YAP-TEAD PPI Disruptors
    Awoonor-Williams, Ernest
    Dickson, Callum J.
    Furet, Pascal
    Golosov, Andrei A.
    Hornak, Viktor
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 63 (08) : 2520 - 2531
  • [49] Discovery and characterization of a novel small molecule brain penetrant PD-L1 inhibitor
    Zhang, Yongxian
    Zhang, Mingming
    Zhao, Baowei
    Yu, Hongping
    Xu, Yao-Chang
    Chen, Zhui
    Ying, Haiyan
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [50] A novel small molecule inhibitor of the Notch transcription activation complex
    Lehal, Rajwinder
    Frismantas, Viktoras
    Loubery, Sylvain
    Reinmuller, Viktoria
    Turcatti, Gerardo
    Gonzalez-Gaitan, Marcos
    Bourquin, Jean-Pierre
    Radtke, Freddy
    CANCER RESEARCH, 2016, 76