Discovery of a novel small molecule inhibitor of the YAP1/TAZ-TEAD transcriptional complex

被引：0
|
作者：
Moure, Casey J. [1 ]
Sondey, Christopher [1 ]
Cheng, Mangeng [1 ]
Mansueto, My [1 ]
Fernandez, Rafael [1 ]
Schneider, Sebastian E. [1 ]
Ramirez, Julia V. [1 ]
Long, Brian [1 ]
DiMauro, Erin [1 ]
Vara, Brandon [1 ]
Yeung, Charles [1 ]
Achab, Abe [1 ]
Lim, Jongwon [1 ]
Kim, Ronald [1 ]
Zarate, Cayetana [1 ]
Bennett, Jonathan [1 ]
Palte, Rachel [1 ]
Foti, Robert [1 ]
Simov, Vladimir [1 ]
Barry, Evan [1 ]
机构：
[1] Merck Sharp & Dohme Ltd, Boston, MA USA
来源：
CANCER RESEARCH | 2022年 / 82卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3938
引用
收藏
页数：2
相关论文
共 50 条
  • [21] YAP/TAZ-TEAD is a novel transcriptional regulator of genes encoding steroidogenic enzymes in rat granulosa cells and KGN cells
    Mizutani, Tetsuya
    Orisaka, Makoto
    Kawabe, Shinya
    Morichika, Ririko
    Uesaka, Miki
    Yoshida, Yoshio
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2023, 559
  • [22] Activation of Hepatocyte Growth Factor/MET Signaling as a Mechanism of Acquired Resistance to a Novel YAP1/TEAD Small Molecule Inhibitor
    Moure, Casey J.
    Vara, Brandon
    Cheng, Mangeng M.
    Sondey, Christopher
    Muise, Eric
    Park, Eunsil
    Vela Ramirez, Julia Eulalia
    Su, Dan
    D'Souza, Shanti
    Yan, Qingyun
    Yeung, Charles S.
    Zhang, Minjia
    Mansueto, My Sam
    Linn, Doug
    Buchanan, Mark
    Foti, Robert
    Dimauro, Erin
    Long, Brian
    Simov, Vladimir
    Barry, Evan R.
    MOLECULAR CANCER THERAPEUTICS, 2024, 23 (08) : 1095 - 1108
  • [23] Identification and target deconvolution of novel small molecule inhibitors of oncogenic YAP1/TAZ activity
    Lange, M.
    Nicke, B.
    Naujoks, J.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S157 - S157
  • [24] Antitumor activity of novel and potent YAP/TAZ-TEAD inhibitorstargeting the Hippo pathway in solid tumors
    Kim, Jisook
    Jung, Seung Hyun
    Han, Seon Yeong
    Yoon, Jihee
    Kim, Minjeong
    Byun, Jooyun
    Moon, Heesun
    Lee, Eunyoung
    Kim, Yu-Yon
    Park, Hyunjin
    Jeon, Ye
    Ahn, Young Gil
    Kim, Young Hoon
    Suh, Kwee Hyun
    CANCER RESEARCH, 2023, 83 (07)
  • [25] Discovery of novel potent allosteric inhibitors of YAP/TAZ-TEAD transcription for the treatment of multiple solid tumor types addicted to Hippo signaling
    Versele, Matthias
    Candi, Aurelie
    Nijs, Marnik
    Haeck, Wanda
    Klaassen, Hugo
    Smets, Wim
    Spieser, Stephane
    Vanderhoydonck, Bart
    Marchand, Arnaud
    Chaltin, Patrick
    Sansores, Leticia
    Halder, Georg
    CANCER RESEARCH, 2020, 80 (16)
  • [26] Discovery of ETS-003, a potent and selective YAP/TAZ-TEAD PPI inhibitor with broad anti-tumor activity in Hippo-YAP aberrant cancers
    Lu, Jiajun
    Gao, Ming
    He, Hao
    Feng, Lijian
    Gao, Zhenting
    Cui, Wenqi
    Yang, Kun
    Lu, Jiting
    Zheng, Qiangang
    Zhu, Jidong
    Guo, Xin
    CANCER RESEARCH, 2023, 83 (07)
  • [27] Discovery of a first-in-class TEAD inhibitor which directly inhibits YAP/TAZ-TEAD protein-protein interaction and shows a potent anti-tumor effect in malignant pleural mesothelioma
    Kaneda, Ayumi
    Seike, Toshihiro
    Uemori, Takeshi
    Myojo, Kensuke
    Aida, Kensuke
    Danjo, Tomohiro
    Nakajima, Takahiro
    Yamaguchi, Daisuke
    Hamada, Tomoko
    Tsuji, Yoshiro
    Hamaguchi, Kaori
    Yasunaga, Mai
    Otsubo, Nobumasa
    Onodera, Hideyuki
    Nishiya, Yoichi
    Suzuki, Michihiko
    Saito, Junichi
    Ishii, Toshihiko
    Nakai, Ryuichiro
    CANCER RESEARCH, 2019, 79 (13)
  • [28] YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
    Stein, Claudia
    Bardet, Anais Flore
    Roma, Guglielmo
    Bergling, Sebastian
    Clay, Ieuan
    Ruchti, Alexandra
    Agarinis, Claudia
    Schmelzle, Tobias
    Bouwmeester, Tewis
    Schuebeler, Dirk
    Bauer, Andreas
    PLOS GENETICS, 2015, 11 (08):
  • [29] yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets
    Vazquez-Marin, Javier
    Arturo Gutierrez-Triana, Jose
    Almuedo-Castillo, Maria
    Buono, Lorena
    Luis Gomez-Skarmeta, Jose
    Luis Mateo, Juan
    Wittbrodt, Joachim
    Ramon Martinez-Morales, Juan
    DEVELOPMENT, 2019, 146 (13):
  • [30] Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity
    Gridnev, Artem
    Maity, Subhajit
    Misra, Jyoti R. R.
    FRONTIERS IN ONCOLOGY, 2022, 12
12345