Genetic Variation in the α7 Nicotinic Acetylcholine Receptor is Associated with Delusional Symptoms in Alzheimer's Disease

被引：32
|
作者：
Carson, Robyn [1 ]
Craig, David [1 ]
Hart, Dominic [1 ]
Todd, Stephen [1 ]
McCuinness, Bernadette [1 ]
Johnston, Janet A. [1 ]
O'Neill, Francis A. [1 ]
Ritchie, Craig W. [2 ]
Passmore, A. Peter [1 ]
机构：
[1] Queens Univ Belfast, Sch Med & Dent, Div Psychiat & Neurosci, Belfast BT9 7BL, Antrim, North Ireland
[2] Univ London Imperial Coll Sci Technol & Med, Div Neurosci, Claybrook Ctr, London W6 8LN, England
来源：
NEUROMOLECULAR MEDICINE | 2008年 / 10卷 / 04期
关键词：
CHRNA7; Haplotype; Polymorphism; Psychosis; Delusions; Hallucinations;
D O I：
10.1007/s12017-008-8048-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Psychotic symptoms are common in Alzheimer's disease (AD) and have a negative impact oil quality of life. It is suggested that psychotic symptoms may be attributed to genetic risk factors which are revealed during neurodegeneration. CHRNA7, the gene for the alpha 7 nicotinic acetylcholine receptor, has been associated with schizophrenia in linkage and association Studies. Hence we investigated single SNPs and haplotypes in CHRNA7 in relation to AD with psychosis in a large, well-characterised and previously described cohort within the Northern Ireland population. A significant association between delusions and the T allele of rs6494223 (P = 0.014, OR = 1.63, Cl 1.22-2.17) was found. This suggests that the alpha 7 receptor may be a suitable target for the treatment of AD with psychosis.
引用
收藏
页码：377 / 384
页数：8
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