Genetic Variation in the α7 Nicotinic Acetylcholine Receptor is Associated with Delusional Symptoms in Alzheimer's Disease

被引：32

作者：

Carson, Robyn ^{[1
]}

Craig, David ^{[1
]}

Hart, Dominic ^{[1
]}

Todd, Stephen ^{[1
]}

McCuinness, Bernadette ^{[1
]}

Johnston, Janet A. ^{[1
]}

O'Neill, Francis A. ^{[1
]}

Ritchie, Craig W. ^{[2
]}

Passmore, A. Peter ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Med & Dent, Div Psychiat & Neurosci, Belfast BT9 7BL, Antrim, North Ireland

[2] Univ London Imperial Coll Sci Technol & Med, Div Neurosci, Claybrook Ctr, London W6 8LN, England

来源：

NEUROMOLECULAR MEDICINE | 2008年 / 10卷 / 04期

关键词：

CHRNA7; Haplotype; Polymorphism; Psychosis; Delusions; Hallucinations;

D O I：

10.1007/s12017-008-8048-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Psychotic symptoms are common in Alzheimer's disease (AD) and have a negative impact oil quality of life. It is suggested that psychotic symptoms may be attributed to genetic risk factors which are revealed during neurodegeneration. CHRNA7, the gene for the alpha 7 nicotinic acetylcholine receptor, has been associated with schizophrenia in linkage and association Studies. Hence we investigated single SNPs and haplotypes in CHRNA7 in relation to AD with psychosis in a large, well-characterised and previously described cohort within the Northern Ireland population. A significant association between delusions and the T allele of rs6494223 (P = 0.014, OR = 1.63, Cl 1.22-2.17) was found. This suggests that the alpha 7 receptor may be a suitable target for the treatment of AD with psychosis.

引用

页码：377 / 384

页数：8

共 50 条

[31] Dissociating β-Amyloid from α7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes α7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain (Publication with Expression of Concern)
Wang, Hoau-Yan
Stucky, Andres
Liu, JingJing
Shen, Changpeng
Trocme-Thibierge, Caryn
Morain, Philippe
JOURNAL OF NEUROSCIENCE, 2009, 29 (35): : 10961 - 10973
[32] α4 but not α3 and α7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer' s disease
Martin-Ruiz, CM
Court, JA
Molnar, E
Lee, M
Gotti, C
Mamalaki, A
Tsouloufis, T
Tzartos, S
Ballard, C
Perry, RH
Perry, EK
JOURNAL OF NEUROCHEMISTRY, 1999, 73 (04) : 1635 - 1640
[33] Targeting the alpha 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons
D'Andrea, MR
Nagele, RG
CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (06) : 677 - 684
[34] The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor
Small, David H.
Maksel, Danuta
Kerr, Megan L.
Ng, Judy
Hou, Xu
Chu, Cindy
Mehrani, Hossein
Unabia, Sharon
Azari, Michael F.
Loiacono, Richard
Aguilar, Marie-Isabel
Chebib, Mary
JOURNAL OF NEUROCHEMISTRY, 2007, 101 (06) : 1527 - 1538
[35] α7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
Mathew, Shiny V.
Law, Amanda J.
Lipska, Barbara K.
Davila-Garcia, Martha I.
Zamora, Eduardo D.
Mitkus, Shruti N.
Vakkalanka, Radhakrishna
Straub, Richard E.
Weinberger, Daniel R.
Kleinman, Joel E.
Hyde, Thomas M.
HUMAN MOLECULAR GENETICS, 2007, 16 (23) : 2921 - 2932
[36] The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease
Igor C. Fontana
Amit Kumar
Agneta Nordberg
Nature Reviews Neurology, 2023, 19 : 278 - 288
[37] The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease
Fontana, Igor C.
Kumar, Amit
Nordberg, Agneta
NATURE REVIEWS NEUROLOGY, 2023, 19 (05) : 278 - 288
[38] The role of nicotinic acetylcholine receptors in Alzheimer's disease
Oddo, S
LaFerla, FM
JOURNAL OF PHYSIOLOGY-PARIS, 2006, 99 (2-3) : 172 - 179
[39] Cellular expression of α7 nicotinic acetylcholine receptor protein in the temporal cortex in Alzheimer's and Parkinson's disease -: A stereological approach
Banerjee, C
Nyengaard, JR
Wevers, A
de Vos, RAI
Steur, ENHJ
Lindstrom, J
Pilz, K
Nowacki, S
Bloch, W
Schröder, H
NEUROBIOLOGY OF DISEASE, 2000, 7 (06) : 666 - 672
[40] Nicotinic receptor of acetylcholine in Parkinson's disease
Fukuyama, H
MOVEMENT DISORDERS, 2006, 21 : S28 - S28

← 1 2 3 4 5 →