Genetic Variation in the α7 Nicotinic Acetylcholine Receptor is Associated with Delusional Symptoms in Alzheimer's Disease

被引：32

作者：

Carson, Robyn ^{[1
]}

Craig, David ^{[1
]}

Hart, Dominic ^{[1
]}

Todd, Stephen ^{[1
]}

McCuinness, Bernadette ^{[1
]}

Johnston, Janet A. ^{[1
]}

O'Neill, Francis A. ^{[1
]}

Ritchie, Craig W. ^{[2
]}

Passmore, A. Peter ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Med & Dent, Div Psychiat & Neurosci, Belfast BT9 7BL, Antrim, North Ireland

[2] Univ London Imperial Coll Sci Technol & Med, Div Neurosci, Claybrook Ctr, London W6 8LN, England

来源：

NEUROMOLECULAR MEDICINE | 2008年 / 10卷 / 04期

关键词：

CHRNA7; Haplotype; Polymorphism; Psychosis; Delusions; Hallucinations;

D O I：

10.1007/s12017-008-8048-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Psychotic symptoms are common in Alzheimer's disease (AD) and have a negative impact oil quality of life. It is suggested that psychotic symptoms may be attributed to genetic risk factors which are revealed during neurodegeneration. CHRNA7, the gene for the alpha 7 nicotinic acetylcholine receptor, has been associated with schizophrenia in linkage and association Studies. Hence we investigated single SNPs and haplotypes in CHRNA7 in relation to AD with psychosis in a large, well-characterised and previously described cohort within the Northern Ireland population. A significant association between delusions and the T allele of rs6494223 (P = 0.014, OR = 1.63, Cl 1.22-2.17) was found. This suggests that the alpha 7 receptor may be a suitable target for the treatment of AD with psychosis.

引用

页码：377 / 384

页数：8

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