Synthesis of 2-substituted cyclohexene derivatives through cross-coupling reactions via π-allylmetal intermediate using N-heterocyclic carbenes (NHCs) as ligands

被引：2
|
作者：
Yamazaki, Tetsuro [1 ]
Sato, Yoshihiro [1 ]
机构：
[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
来源：
SYNTHESIS-STUTTGART | 2008年 / 17期
基金：
日本学术振兴会;
关键词：
N-heterocyclic carbene (NHC); cross-coupling; Migita-Kosugi-Stille reaction; Kumada-Tamao-Coriiu reaction; palladium; nickel;
D O I：
10.1055/s-2008-1067222
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium- or nickel-catalyzed cross-coupling reactions of 2-substituted cyclohexenes, which are generally less reactive than those having no substituent at the C2 position, with organotin reagents (Migita-Kosugi-Stille coupling) or with Grigard reagents (Kumada-Tamao-Corriu coupling) using a NHC as a ligand was investigated. It was found that NHCs are effective as ligands for these reactions, giving the corresponding cross-coupling products in good yields.
引用
收藏
页码：2830 / 2834
页数：5
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