Synthesis of 2-substituted cyclohexene derivatives through cross-coupling reactions via π-allylmetal intermediate using N-heterocyclic carbenes (NHCs) as ligands

被引：2

作者：

Yamazaki, Tetsuro ^{[1
]}

Sato, Yoshihiro ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

SYNTHESIS-STUTTGART | 2008年 / 17期

基金：

日本学术振兴会;

关键词：

N-heterocyclic carbene (NHC); cross-coupling; Migita-Kosugi-Stille reaction; Kumada-Tamao-Coriiu reaction; palladium; nickel;

D O I：

10.1055/s-2008-1067222

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium- or nickel-catalyzed cross-coupling reactions of 2-substituted cyclohexenes, which are generally less reactive than those having no substituent at the C2 position, with organotin reagents (Migita-Kosugi-Stille coupling) or with Grigard reagents (Kumada-Tamao-Corriu coupling) using a NHC as a ligand was investigated. It was found that NHCs are effective as ligands for these reactions, giving the corresponding cross-coupling products in good yields.

引用

页码：2830 / 2834

页数：5

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