C(sp3)-H Peroxidation of 3-Substituted Indolin-2-ones under Metal-Free Conditions

被引：14
|
作者：
Ying, Wei-Wei [1 ]
Zhu, Wen-Ming [1 ]
Gao, Zhanghua [1 ]
Liang, Hongze [1 ]
Wei, Wen-Ting [1 ]
机构：
[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China
来源：
SYNLETT | 2018年 / 29卷 / 05期
关键词：
C(sp(3))-H peroxidation; metal-free; 3-substituted indolin-2-ones; tert-butyl hydroperoxide; H BOND FUNCTIONALIZATION; TERT-BUTYL PERESTERS; C-H; ALPHA-KETOAMIDES; COUPLING REACTIONS; ARYL HALIDES; OXIDATION; HYDROPEROXIDES; AMINATION; ALDEHYDES;
D O I：
10.1055/s-0036-1591520
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A C( sp3)- H peroxidation of 3- substituted indolin- 2- ones through radical coupling reaction has been developed under metal- free conditions. Using tert- butyl hydroperoxide both as an oxidant and as a peroxidation reagent to couple with the C( sp3)- H bonds of 3- substituted indolin- 2- ones can form a new C- O bond without using any additives. This simple strategy provides a green and efficient approach to 3- peroxyindolin- 2- ones in moderate to excellent yields. The resulting 3- peroxyindolin- 2- ones could be further transformed into 3- hydroxyindolin- 2- ones.
引用
收藏
页码：663 / 667
页数：5
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