C(sp3)-H Peroxidation of 3-Substituted Indolin-2-ones under Metal-Free Conditions

被引：14

作者：

Ying, Wei-Wei ^{[1
]}

Zhu, Wen-Ming ^{[1
]}

Gao, Zhanghua ^{[1
]}

Liang, Hongze ^{[1
]}

Wei, Wen-Ting ^{[1
]}

机构：

[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China

来源：

SYNLETT | 2018年 / 29卷 / 05期

关键词：

C(sp(3))-H peroxidation; metal-free; 3-substituted indolin-2-ones; tert-butyl hydroperoxide; H BOND FUNCTIONALIZATION; TERT-BUTYL PERESTERS; C-H; ALPHA-KETOAMIDES; COUPLING REACTIONS; ARYL HALIDES; OXIDATION; HYDROPEROXIDES; AMINATION; ALDEHYDES;

D O I：

10.1055/s-0036-1591520

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A C( sp3)- H peroxidation of 3- substituted indolin- 2- ones through radical coupling reaction has been developed under metal- free conditions. Using tert- butyl hydroperoxide both as an oxidant and as a peroxidation reagent to couple with the C( sp3)- H bonds of 3- substituted indolin- 2- ones can form a new C- O bond without using any additives. This simple strategy provides a green and efficient approach to 3- peroxyindolin- 2- ones in moderate to excellent yields. The resulting 3- peroxyindolin- 2- ones could be further transformed into 3- hydroxyindolin- 2- ones.

引用

页码：663 / 667

页数：5

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