Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay

被引：34

作者：

Goldenberger, Daniel ^{[1
,2
]}

Leuzinger, Karoline ^{[3
]}

Sogaard, Kirstine K. ^{[1
,2
,4
]}

Gosert, Rainer ^{[3
]}

Roloff, Tim ^{[1
,2
,4
]}

Naegele, Klaudia ^{[3
]}

Cuenod, Aline ^{[4
]}

Mari, Alfredo ^{[4
]}

Seth-Smith, Helena ^{[1
,2
,4
]}

Rentsch, Katharina ^{[5
]}

Hinic, Vladimira ^{[1
,2
]}

Hirsch, Hans H. ^{[3
,6
,7
]}

Egli, Adrian ^{[1
,2
,4
]}

机构：

[1] Univ Hosp Basel, Lab Med, Clin Bacteriol & Mycol, Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] Univ Hosp Basel, Lab Med, Clin Virol, Basel, Switzerland

[4] Univ Basel, Dept Biomed, Lab Med, Appl Microbiol Res, Basel, Switzerland

[5] Univ Hosp Basel, Lab Med, Basel, Switzerland

[6] Univ Hosp Basel, Infect Dis & Hosp Epidemiol, Basel, Switzerland

[7] Univ Basel, Dept Biomed, Transplantat & Clin Virol, Basel, Switzerland

来源：

JOURNAL OF VIROLOGICAL METHODS | 2020年 / 284卷

关键词：

SARS-CoV-2; COVID-19; GeneXpert; Respiratory infection; Viruses; Diagnostics; PCR; NAT; COBAS; 6800;

D O I：

10.1016/j.jviromet.2020.113925

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. We validated the novel Xpert Xpress SARS-CoV-2 assay using a commercial nucleic acid testing (Roche Cobas 6800). We found an excellent concordance over a range of SARS-CoV-2 loads and across established human coronaviruses.

引用

页数：3

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