Brief validation of the novel GeneXpert Xpress SARS-CoV-2 PCR assay

被引：34
|
作者：
Goldenberger, Daniel [1 ,2 ]
Leuzinger, Karoline [3 ]
Sogaard, Kirstine K. [1 ,2 ,4 ]
Gosert, Rainer [3 ]
Roloff, Tim [1 ,2 ,4 ]
Naegele, Klaudia [3 ]
Cuenod, Aline [4 ]
Mari, Alfredo [4 ]
Seth-Smith, Helena [1 ,2 ,4 ]
Rentsch, Katharina [5 ]
Hinic, Vladimira [1 ,2 ]
Hirsch, Hans H. [3 ,6 ,7 ]
Egli, Adrian [1 ,2 ,4 ]
机构：
[1] Univ Hosp Basel, Lab Med, Clin Bacteriol & Mycol, Basel, Switzerland
[2] Univ Basel, Basel, Switzerland
[3] Univ Hosp Basel, Lab Med, Clin Virol, Basel, Switzerland
[4] Univ Basel, Dept Biomed, Lab Med, Appl Microbiol Res, Basel, Switzerland
[5] Univ Hosp Basel, Lab Med, Basel, Switzerland
[6] Univ Hosp Basel, Infect Dis & Hosp Epidemiol, Basel, Switzerland
[7] Univ Basel, Dept Biomed, Transplantat & Clin Virol, Basel, Switzerland
来源：
JOURNAL OF VIROLOGICAL METHODS | 2020年 / 284卷
关键词：
SARS-CoV-2; COVID-19; GeneXpert; Respiratory infection; Viruses; Diagnostics; PCR; NAT; COBAS; 6800;
D O I：
10.1016/j.jviromet.2020.113925
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. We validated the novel Xpert Xpress SARS-CoV-2 assay using a commercial nucleic acid testing (Roche Cobas 6800). We found an excellent concordance over a range of SARS-CoV-2 loads and across established human coronaviruses.
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