RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

被引:0
|
作者
Hatzivassiliou, Georgia
Song, Kyung
Yen, Lvana
Brandhuber, Barbara J.
Anderson, Daniel J.
Alvarado, Ryan
Ludlam, Mary Jc
Stokoe, David
Gloor, Susan L.
Vigers, Guy
Morales, Tony
Aliagas, Ignacio
Liu, Bonnie
Sideris, Steve
Hoeflich, Klaus
Jaiswal, Bijay S.
Seshagiri, Sonnasekar
Koeppen, Hartmut
Belvin, Marcia
Friedman, Lori S.
Malek, Shiva
机构
关键词
D O I
10.1158/1538-7445.AM10-5753
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5753
引用
收藏
页数:3
相关论文
共 50 条
  • [11] RAF inhibitors that evade paradoxical MAPK pathway activation
    Zhang, Chao
    Spevak, Wayne
    Zhang, Ying
    Burton, Elizabeth A.
    Ma, Yan
    Habets, Gaston
    Zhang, Jiazhong
    Lin, Jack
    Ewing, Todd
    Matusow, Bernice
    Tsang, Garson
    Marimuthu, Adhirai
    Cho, Hanna
    Wu, Guoxian
    Wang, Weiru
    Fong, Daniel
    Hoa Nguyen
    Shi, Songyuan
    Womack, Patrick
    Nespi, Marika
    Shellooe, Rafe
    Carias, Heidi
    Powell, Ben
    Light, Emily
    Sanftner, Laura
    Walters, Jason
    Tsai, James
    West, Brian L.
    Visor, Gary
    Rezaei, Hamid
    Lin, Paul S.
    Nolop, Keith
    Ibrahim, Prabha N.
    Hirth, Peter
    Bollag, Gideon
    NATURE, 2015, 526 (7574) : 583 - U298
  • [12] The Ras/Raf/MAPK pathway
    Molina, Julian R.
    Adjei, Alex A.
    JOURNAL OF THORACIC ONCOLOGY, 2006, 1 (01) : 7 - 9
  • [13] Response to RAF/MEK/ERK inhibitors in patients with RAS altered and wild-type tumors
    Gouda, Mohamed Alaa
    Lin, Heather Y.
    Kang, Lei
    Le, Hung
    Dumbrava, Ecaterina Elena
    Fu, Siqing
    Karp, Daniel D.
    Tsimberidou, Apostolia Maria
    Naing, Aung
    Piha-Paul, Sarina A.
    Pohlmann, Paula R.
    Ahnert, Jordi Rodon
    Yap, Timothy A.
    Meric-Bernstam, Funda
    Hong, David S.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [14] Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
    Marusiak, Anna A.
    Edwards, Zoe C.
    Hugo, Willy
    Trotter, Eleanor W.
    Girotti, Maria R.
    Stephenson, Natalie L.
    Kong, Xiangju
    Gartside, Michael G.
    Fawdar, Shameem
    Hudson, Andrew
    Breitwieser, Wolfgang
    Hayward, Nicholas K.
    Marais, Richard
    Lo, Roger S.
    Brognard, John
    NATURE COMMUNICATIONS, 2014, 5
  • [15] Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
    Anna A. Marusiak
    Zoe C. Edwards
    Willy Hugo
    Eleanor W. Trotter
    Maria R. Girotti
    Natalie L. Stephenson
    Xiangju Kong
    Michael G. Gartside
    Shameem Fawdar
    Andrew Hudson
    Wolfgang Breitwieser
    Nicholas K. Hayward
    Richard Marais
    Roger S. Lo
    John Brognard
    Nature Communications, 5
  • [16] Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
    Marusiak, A. A.
    Edwards, Z. C.
    Hugo, W.
    Trotter, E. W.
    Girotti, M. R.
    Stephenson, N. L.
    Kong, X.
    Gartside, M. G.
    Fawdar, S.
    Hudson, A.
    Breitwieser, W.
    Hayward, N. K.
    Marais, R.
    Lo, R. S.
    Brognard, J.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : 29 - 30
  • [17] Allosteric activation of RAF in the MAPK signaling pathway
    Tsai, Chung-Jung
    Nussinov, Ruth
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2018, 53 : 100 - 106
  • [18] How blocking Raf activates the MAPK pathway
    McCormick, Frank
    PIGMENT CELL & MELANOMA RESEARCH, 2010, 23 (02) : 187 - 189
  • [19] Understanding the effects of RAF inhibitors on RAF signaling in B-RAF V600E mutant versus wild type tumors
    Yen, Ivana
    Song, Kyung
    Stokoe, David
    Brandhuber, Barbara
    Gloor, Susan
    Aliagas, Ignacio
    Anderson, Daniel
    Morales, Tony
    Vigers, Guy
    Ludlam, Mary
    Alvarado, Ryan
    Liu, Bonnie
    Sideris, Steve
    Ramaswamy, Sreema
    Heise, Christopher
    Belvin, Marcia
    Friedman, Lou
    Hatzivassiliou, Georgia
    Malek, Shiva
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [20] Wild-type blocking PCR for sensitive detection of minority B-raf mutations in an excess of wild-type DNA
    Dominguez, PL
    Kolodney, MS
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 124 (04) : A149 - A149