BINOL-Salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes

被引：104
|
作者：
Li, ZB [1 ]
Pu, L [1 ]
机构：
[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 06期
关键词：
D O I：
10.1021/ol0498139
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The BINOL-Salen compound (-)-1 can catalyze the addition of both aryl- and alkylalkynes to aromatic aldehydes at room temperature with high enantioselectivity (86-97% ee). The conditions for this catalytic process are both mild and simple. Unlike most other BINOL-based catalysts, using ligand (-)-1 not only avoids heating or cooling but also does not require the addition of Ti((OPr)-Pr-i)(4).
引用
收藏
页码：1065 / 1068
页数：4
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