Highly enantioselective aryl additions of [AlAr3(thf)] to ketones catalyzed by a Titanium(IV) catalyst of (S)-Binol

被引：82
|
作者：
Chen, Chien-An [1 ]
Wu, Kuo-Hui [1 ]
Gau, Han-Mou [1 ]
机构：
[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 28期
关键词：
aluminum; asymmetric synthesis; homogeneous catalysis; ketones; titanium;
D O I：
10.1002/anie.200701201
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Chiral transfer: Novel asymmetric aryl transfers from [AlAr3(thf)] to a wide variety of ketones are catalyzed by an in situ generated titanium species with (S)-binol as the chiral ligand. The reaction affords tertiary alcohols with enantioselectivities up to 97% ee (see scheme). Binol = 2,2′-dihydroxy-1,1′-binaphthyl. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：5373 / 5376
页数：4
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