Highly enantioselective aryl additions of [AlAr3(thf)] to ketones catalyzed by a Titanium(IV) catalyst of (S)-Binol

被引：82

作者：

Chen, Chien-An ^{[1
]}

Wu, Kuo-Hui ^{[1
]}

Gau, Han-Mou ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 28期

关键词：

aluminum; asymmetric synthesis; homogeneous catalysis; ketones; titanium;

D O I：

10.1002/anie.200701201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Chiral transfer: Novel asymmetric aryl transfers from [AlAr3(thf)] to a wide variety of ketones are catalyzed by an in situ generated titanium species with (S)-binol as the chiral ligand. The reaction affords tertiary alcohols with enantioselectivities up to 97% ee (see scheme). Binol = 2,2′-dihydroxy-1,1′-binaphthyl. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5373 / 5376

页数：4

共 22 条

[21] Asymmetric synthesis .28. Enantioselective reduction of aromatic ketones catalyzed by new chiral catalyst-(4R,8R,9S)-Camphane[8,9-b]-1,3,2-oxathioborolidine
Jiang, YZ
Feng, XM
Gong, LZ
Li, Z
Yang, GS
Mi, AQ
CHINESE CHEMICAL LETTERS, 1996, 7 (05) : 415 - 418
[22] A highly enantioselective hetero-Diels-Alder reaction of aldehydes with Danishefsky's diene catalyzed by chiral titanium(IV) 5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-bi-2-naphthol complexes
Wang, B
Feng, XM
Huang, YZ
Liu, H
Cui, X
Jiang, YZ
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (07): : 2175 - 2182

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