BINOL-Salen-catalyzed highly enantioselective alkyne additions to aromatic aldehydes

被引：104

作者：

Li, ZB ^{[1
]}

Pu, L ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1021/ol0498139

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The BINOL-Salen compound (-)-1 can catalyze the addition of both aryl- and alkylalkynes to aromatic aldehydes at room temperature with high enantioselectivity (86-97% ee). The conditions for this catalytic process are both mild and simple. Unlike most other BINOL-based catalysts, using ligand (-)-1 not only avoids heating or cooling but also does not require the addition of Ti((OPr)-Pr-i)(4).

引用

页码：1065 / 1068

页数：4

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