T3P®-promoted Kabachnik-Fields reaction: an efficient synthesis of α-aminophosphonates

被引：44

作者：

Milen, Matyas ^{[1
,2
]}

Abranyi-Balogh, Peter ^{[2
]}

Dancso, Andras ^{[1
]}

Frigyes, David ^{[1
]}

Pongo, Laszlo ^{[1
]}

Keglevich, Gyoergy ^{[2
]}

机构：

[1] Egis Pharmaceut Plc, Div Chem Res, H-1475 Budapest, Hungary

[2] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 40期

关键词：

alpha-Aminophosphonates; T3P (R); Kabachnik-Fields reaction; Three-component condensation; Mechanism; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; PROPYLPHOSPHONIC ANHYDRIDE T3P(R); AMINO PHOSPHONATES; SOLVENT-FREE; 3-COMPONENT SYNTHESIS; MEDIATED SYNTHESIS; FACILE SYNTHESIS; INHIBITORS; ALDEHYDES;

D O I：

10.1016/j.tetlet.2013.07.145

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient synthesis of alpha-aminophosphonates has been developed via the one-pot three-component reactions of aldehydes, amines, and trialkyl phosphites. The reactions occurred rapidly at room temperature in the presence of 1 equiv of propylphosphonic anhydride (T3P (R)) as the condensing agent, and the alpha-aminophosphonate products were obtained in high yields. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：5430 / 5433

页数：4

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