T3P®-promoted Kabachnik-Fields reaction: an efficient synthesis of α-aminophosphonates

被引：44
|
作者：
Milen, Matyas [1 ,2 ]
Abranyi-Balogh, Peter [2 ]
Dancso, Andras [1 ]
Frigyes, David [1 ]
Pongo, Laszlo [1 ]
Keglevich, Gyoergy [2 ]
机构：
[1] Egis Pharmaceut Plc, Div Chem Res, H-1475 Budapest, Hungary
[2] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 40期
关键词：
alpha-Aminophosphonates; T3P (R); Kabachnik-Fields reaction; Three-component condensation; Mechanism; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; PROPYLPHOSPHONIC ANHYDRIDE T3P(R); AMINO PHOSPHONATES; SOLVENT-FREE; 3-COMPONENT SYNTHESIS; MEDIATED SYNTHESIS; FACILE SYNTHESIS; INHIBITORS; ALDEHYDES;
D O I：
10.1016/j.tetlet.2013.07.145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient synthesis of alpha-aminophosphonates has been developed via the one-pot three-component reactions of aldehydes, amines, and trialkyl phosphites. The reactions occurred rapidly at room temperature in the presence of 1 equiv of propylphosphonic anhydride (T3P (R)) as the condensing agent, and the alpha-aminophosphonate products were obtained in high yields. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5430 / 5433
页数：4
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