Recent progress of antibacterial natural products: Future antibiotics candidates

被引：56

作者：

Dai, Jiangkun ^{[1
,2
,3
]}

Han, Rui ^{[4
]}

Xu, Yujie ^{[4
]}

Li, Na ^{[5
]}

Wang, Junru ^{[1
,4
]}

Dan, Wenjia ^{[3
,4
]}

机构：

[1] Northwest A&F Univ, Coll Vet Med, Xian, Shaanxi, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China

[3] Weifang Med Univ, Sch Life Sci & Technol, Weifang, Shandong, Peoples R China

[4] Northwest A&F Univ, Coll Chem & Pharm, Xian, Shaanxi, Peoples R China

[5] Northwest Univ, Coll Food Sci & Technol, Xian, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2020年 / 101卷

基金：

中国国家自然科学基金;

关键词：

Natural Products; Antibacterial; Drug Candidates; RESISTANT STAPHYLOCOCCUS-AUREUS; MONOTERPENOID INDOLE ALKALOIDS; ENDOPHYTIC FUNGUS; ANTIMICROBIAL ACTIVITY; STRUCTURE ELUCIDATION; ACID-DERIVATIVES; A-C; CYCLIC HEXAPEPTIDE; DIPHENYL ETHERS; METABOLITES;

D O I：

10.1016/j.bioorg.2020.103922

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of novel antibacterial molecules plays a key role in solving the current antibiotic crisis issue. Natural products have long been an important source of drug discovery. Herein, we reviewed 256 natural products from 11 structural classes in the period of 2016-01/2020, which were selected by SciFinder with new compounds or new structures and MICs lower than 10 mu g/mL or 10 mu M as criterions. This review will provide some effective antibacterial lead compounds for medicinal chemists, which will promote the antibiotics research based on natural products to the next level.

引用

页数：25

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