Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities

被引:3
|
作者
Liao, Yanmei [1 ]
Lv, Fei [1 ]
Quan, Tianwen [1 ]
Wang, Chuan [2 ]
Li, Jike [2 ]
机构
[1] Publ Hlth Clin Ctr Chengdu, Dept Pharm, Chengdu, Sichuan, Peoples R China
[2] Publ Hlth Clin Ctr Chengdu, Sci Res & Teaching Dept, Chengdu, Sichuan, Peoples R China
关键词
liver disease; natural products; flavonoids; novel therapeutic drugs; hepatoprotective effect; INDUCED HEPATIC-FIBROSIS; HIGH-FAT DIET; NF-KAPPA-B; PURPLE SWEET-POTATO; IN-VITRO; HEPATOCELLULAR-CARCINOMA; PPAR-GAMMA; INDUCED HEPATOTOXICITY; HYDROXYSAFFLOR YELLOW; CARBON-TETRACHLORIDE;
D O I
10.3389/fphar.2024.1485065
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The liver is the largest, important organ and the site for essential biochemical reactions in the human body. It has the function to detoxify toxic substances and synthesize useful biomolecules. Liver diseases related complications represent a significant source of morbidity and mortality worldwide, creating a substantial economic burden. Oxidative stress, excessive inflammation, and dysregulated energy metabolism significantly contributed to liver diseases. Therefore, discovery of novel therapeutic drugs for the treatment of liver diseases are urgently required. For centuries, flavonoids and their preparations which have the beneficial health effects in chronic diseases have been used to treat various human illnesses. Flavonoids mainly include flavones, isoflavones, flavanols, dihydroflavones, dihydroflavonols, anthocyanins and chalcones. The primary objective of this review is to assess the efficacy and safety of flavonoids, mainly from a clinical point of view and considering clinically relevant end-points. We summarized the recent progress in the research of hepatoprotective and molecular mechanisms of different flavonoids bioactive ingredients and also outlined the networks of underlying molecular signaling pathways. Further pharmacology and toxicology research will contribute to the development of natural products in flavonoids and their derivatives as medicines with alluring prospect in the clinical application.
引用
收藏
页数:23
相关论文
共 50 条
  • [1] Natural products in licorice for the therapy of liver diseases: Progress and future opportunities
    Li, Xiaojiaoyang
    Sun, Rong
    Liu, Runping
    PHARMACOLOGICAL RESEARCH, 2019, 144 : 210 - 226
  • [2] Radiomics in liver diseases: Current progress and future opportunities
    Wei, Jingwei
    Jiang, Hanyu
    Gu, Dongsheng
    Niu, Meng
    Fu, Fangfang
    Han, Yuqi
    Song, Bin
    Tian, Jie
    LIVER INTERNATIONAL, 2020, 40 (09) : 2050 - 2063
  • [3] Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities
    Zeng, Zuomei
    Wang, Xinyue
    Cui, Lidan
    Wang, Hongjuan
    Guo, Jian
    Chen, Yucai
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2023, 45 (03) : 2351 - 2371
  • [4] Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases
    Zhou, Zheng
    Li, Jiye
    Zhang, Xiaochuan
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023, 71 (15) : 5902 - 5916
  • [5] Natural Flavonoids and Ferroptosis: Potential Therapeutic Opportunities for Human Diseases
    Zhou, Zheng
    Li, Jiye
    Zhang, Xiaochuan
    Journal of Agricultural and Food Chemistry, 2022,
  • [6] Natural products chemistry: New opportunities, uncertain future
    Meinwald, J
    Eisner, T
    HELVETICA CHIMICA ACTA, 2003, 86 (11) : 3633 - 3637
  • [7] Progress of studies on natural products for glioblastoma therapy
    Xu, Fang
    Yang, Yi-Hui
    Yang, Hong
    Li, Wan
    Hao, Yue
    Zhang, Sen
    Zhang, Yi-Zhi
    Cao, Wan-Xin
    Li, Xiao-Xue
    Du, Guan-Hua
    Ji, Teng-Fei
    Wang, Jin-Hua
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2024, 26 (01) : 154 - 176
  • [8] Effects of Marine Natural Products on Liver Diseases
    Sun, Yandi
    Dong, Yansong
    Cui, Xiaohang
    Guo, Xiaohe
    Zhang, Juan
    Yu, Chong
    Zhang, Man
    Wang, Haifeng
    MARINE DRUGS, 2024, 22 (07)
  • [9] Gene therapy for liver diseases - progress and challenges
    Zabaleta, Nerea
    Unzu, Carmen
    Weber, Nicholas D.
    Gonzalez-Aseguinolaza, Gloria
    NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2023, 20 (05) : 288 - 305
  • [10] Gene therapy for liver diseases — progress and challenges
    Nerea Zabaleta
    Carmen Unzu
    Nicholas D. Weber
    Gloria Gonzalez-Aseguinolaza
    Nature Reviews Gastroenterology & Hepatology, 2023, 20 : 288 - 305