Prenyl Alcohol Production by Expression of Exogenous Isopentenyl Diphosphate Isomerase and Farnesyl Diphosphate Synthase Genes in Escherichia coli

被引：14

作者：

Ohto, Chikara ^{[2
]}

Muramatsu, Masayoshi ^{[2
]}

Obata, Shusei ^{[2
]}

Sakuradani, Eiji ^{[1
]}

Shimizu, Sakayu ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 6068502, Japan

[2] Toyota Motor Co Ltd, Biol Res Lab, Toyota 4718572, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 01期

关键词：

farnesol; geranylgeraniol; lipoate; pyruvate; terpenoid; ISOPRENOID BIOSYNTHESIS; IDENTIFICATION;

D O I：

10.1271/bbb.80446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isopentenyl diphosphate isomerase (idi) and farnesyl diphosphate synthase (ispA) genes were overexpressed in Escherichia coli. The resulting transformant showed 6.8-fold higher production of farnesol (389 mu g/l). In a similar manner, overexpression of idi and mutated ispA led to high production of geranylgeraniol (128 mu g/1).

引用

页码：186 / 188

页数：3

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