GERI-BP002-A, novel inhibitor of Acyl-CoA: Cholesterol acyltransferase produced by Aspergillus fumigatus F93

被引：12
|
作者：
Kim, YK
Lee, HW
Son, KH
Kwon, BM
Jeong, TS
Lee, DH
Shin, J
Seo, YW
Kim, SU
Bok, SH
机构：
[1] KIST,KOREA RES INST BIOSCI & BIOTECHNOL,BIOPROD RES GRP,TAEJON 305600,SOUTH KOREA
[2] KONKUK UNIV,DEPT MICROBIAL ENGN,SEOUL 133701,SOUTH KOREA
[3] KOREA OCEAN RES & DEV INST,MARINE NAT PROD CHEM LAB,ANSAN 425600,SOUTH KOREA
来源：
JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 01期
关键词：
D O I：
10.7164/antibiotics.49.31
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), designated GERI-BP002-A, was isolated from the culture broth of Aspergillus fnmigatus F93 by acetone extraction, EtOAc extraction, SiO2 column chromatography and reverse phase HPLC. Spectroscopic analyses of the compound identified bis (2-hydroxy-3-tert-butyl-5-methylphenyl) methane as the structure and its molecular weight and formula to be 340 and C23H32O2, respectively. GERI-BP002-A inhibited ACAT activity by 50% at the concentration of 50 mu M in an enzyme assay system using rat liver microsomes.
引用
收藏
页码：31 / 36
页数：6
相关论文
共 50 条
  • [31] Total synthesis of (+)-pyripyropene A. A potent, orally bioavailable inhibitor of acyl-CoA:cholesterol acyltransferase
    Nagamitsu, T
    Sunazuka, T
    Obata, R
    Tomoda, H
    Tanaka, H
    Harigaya, Y
    Omura, S
    Smith, AB
    JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (25): : 8126 - 8127
  • [32] Inhibition of acyl-CoA:cholesterol acyltransferase by isohalobacillin, a complex of novel cyclic acylpeptides produced by Bacillus sp A1238
    Hasumi, K
    Takizawa, K
    Takahashi, F
    Park, JK
    Endo, A
    JOURNAL OF ANTIBIOTICS, 1995, 48 (12): : 1419 - 1424
  • [33] Selective inhibition of acyl-CoA:cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species
    Sakai, Kent
    Ohte, Satoshi
    Ohshiro, Taichi
    Matsuda, Daisuke
    Masuma, Rokuro
    Rudel, Lawrence L.
    Tomoda, Hiroshi
    JOURNAL OF ANTIBIOTICS, 2008, 61 (09): : 568 - 572
  • [34] Selective Inhibition of Acyl-CoA:cholesterol Acyltransferase 2 Isozyme by Flavasperone and Sterigmatocystin from Aspergillus Species
    Kent Sakai
    Satoshi Ohte
    Taichi Ohshiro
    Daisuke Matsuda
    Rokuro Masuma
    Lawrence L Rudel
    Hiroshi Tomoda
    The Journal of Antibiotics, 2008, 61 : 568 - 572
  • [35] Pharmacological properties of R-755, a novel acyl-CoA:cholesterol acyltransferase inhibitor, in cholesterol-fed rats, hamsters and rabbits
    Matsui, Y
    Horiuchi, K
    Yamamoto, K
    Kanai, K
    JAPANESE JOURNAL OF PHARMACOLOGY, 2001, 85 (04): : 423 - 433
  • [36] Hypolipidemic and antioxidant activity of the novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor KY-455 in rabbits and hamsters
    Nakamura, S
    Kamiya, S
    Shirahase, H
    Kanda, M
    Yoshimi, A
    Tarumi, T
    Kurahashi, K
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2004, 54 (02): : 102 - 108
  • [37] PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS .2. STRUCTURE ELUCIDATION OF PYRIPYROPENE-A, PYRIPYROPENE-B, PYRIPYROPENE-C AND PYRIPYROPENE-D
    KIM, YK
    TOMODA, H
    NISHIDA, H
    SUNAZUKA, T
    OBATA, R
    OMURA, S
    JOURNAL OF ANTIBIOTICS, 1994, 47 (02): : 154 - 162
  • [38] New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp FKI-2679
    Ohshiro, Taichi
    Matsuda, Daisuke
    Kazuhiro, Takeuchi
    Uchida, Ryuji
    Nonaka, Kenichi
    Masuma, Rokuro
    Tomoda, Hiroshi
    JOURNAL OF ANTIBIOTICS, 2012, 65 (05): : 255 - 262
  • [39] Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation
    Ohta, Masaru
    Takahashi, Kenji
    Kasai, Masayasu
    Shoji, Yoshimichi
    Kunishiro, Kazuyoshi
    Miike, Tomohiro
    Kanda, Mamoru
    Mukai, Chisato
    Shirahase, Hiroaki
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 58 (08) : 1066 - 1076
  • [40] Effect of SMP-500, a novel Acyl-CoA: Cholesterol acyltransferase inhibitor, on serum cholesterol level and LDL cholesterol clearance in hamsters with induced hyperlipidemia
    Ioriya, K
    Kino, K
    Sato, YF
    Ohashi, N
    PHARMACOLOGY, 2002, 66 (02) : 107 - 114
12345