GERI-BP002-A, novel inhibitor of Acyl-CoA: Cholesterol acyltransferase produced by Aspergillus fumigatus F93

被引：12
|
作者：
Kim, YK
Lee, HW
Son, KH
Kwon, BM
Jeong, TS
Lee, DH
Shin, J
Seo, YW
Kim, SU
Bok, SH
机构：
[1] KIST,KOREA RES INST BIOSCI & BIOTECHNOL,BIOPROD RES GRP,TAEJON 305600,SOUTH KOREA
[2] KONKUK UNIV,DEPT MICROBIAL ENGN,SEOUL 133701,SOUTH KOREA
[3] KOREA OCEAN RES & DEV INST,MARINE NAT PROD CHEM LAB,ANSAN 425600,SOUTH KOREA
来源：
JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 01期
关键词：
D O I：
10.7164/antibiotics.49.31
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), designated GERI-BP002-A, was isolated from the culture broth of Aspergillus fnmigatus F93 by acetone extraction, EtOAc extraction, SiO2 column chromatography and reverse phase HPLC. Spectroscopic analyses of the compound identified bis (2-hydroxy-3-tert-butyl-5-methylphenyl) methane as the structure and its molecular weight and formula to be 340 and C23H32O2, respectively. GERI-BP002-A inhibited ACAT activity by 50% at the concentration of 50 mu M in an enzyme assay system using rat liver microsomes.
引用
收藏
页码：31 / 36
页数：6
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