PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY ASPERGILLUS-FUMIGATUS .2. STRUCTURE ELUCIDATION OF PYRIPYROPENE-A, PYRIPYROPENE-B, PYRIPYROPENE-C AND PYRIPYROPENE-D

被引：101
|
作者：
KIM, YK [1 ]
TOMODA, H [1 ]
NISHIDA, H [1 ]
SUNAZUKA, T [1 ]
OBATA, R [1 ]
OMURA, S [1 ]
机构：
[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN
来源：
JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 02期
关键词：
D O I：
10.7164/antibiotics.47.154
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The structures of pyripyropenes A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.
引用
收藏
页码：154 / 162
页数：9
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