Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea

被引：43
|
作者：
Liang, Cheng-Qin [1 ,3 ,4 ]
Shi, Yi-Ming [1 ,3 ]
Luo, Rong-Hua [2 ,3 ]
Li, Xing-Yao [1 ,3 ]
Gao, Zhong-Hua [1 ,3 ]
Li, Xiao-Nian [1 ]
Yang, Liu-Meng [2 ]
Shang, Shan-Zhai [1 ,3 ]
Li, Yan [1 ]
Zheng, Yong-Tang [2 ]
Zhang, Hong-Bin [4 ]
Xiao, Wei-Lie [1 ]
Sun, Han-Dong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China
[2] Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 24期
关键词：
STEREOCONTROLLED SYNTHESIS; LANCIFODILACTONE-G; RING; NORTRITERPENOIDS; ROOTS; ROUTE; CORE;
D O I：
10.1021/ol303168y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C-9 side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC50 value of 47.91 and 32.66 mu g/mL, respectively.
引用
收藏
页码：6362 / 6365
页数：4
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