Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea

被引：43

作者：

Liang, Cheng-Qin ^{[1
,3
,4
]}

Shi, Yi-Ming ^{[1
,3
]}

Luo, Rong-Hua ^{[2
,3
]}

Li, Xing-Yao ^{[1
,3
]}

Gao, Zhong-Hua ^{[1
,3
]}

Li, Xiao-Nian ^{[1
]}

Yang, Liu-Meng ^{[2
]}

Shang, Shan-Zhai ^{[1
,3
]}

Li, Yan ^{[1
]}

Zheng, Yong-Tang ^{[2
]}

Zhang, Hong-Bin ^{[4
]}

Xiao, Wei-Lie ^{[1
]}

Sun, Han-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Yunnan, Peoples R China

[2] Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 24期

关键词：

STEREOCONTROLLED SYNTHESIS; LANCIFODILACTONE-G; RING; NORTRITERPENOIDS; ROOTS; ROUTE; CORE;

D O I：

10.1021/ol303168y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C-9 side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC50 value of 47.91 and 32.66 mu g/mL, respectively.

引用

页码：6362 / 6365

页数：4

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