Cucurbalsaminones A-C, Rearranged Triterpenoids with a 5/6/3/6/5-Fused Pentacyclic Carbon Skeleton from Momordica balsamina, as Multidrug Resistance Reversers

被引：7
|
作者：
Monico, Andreia [1 ]
Ramalhete, Catia [1 ,2 ]
Andre, Vania [3 ]
Spengler, Gabriella [4 ]
Mulhovo, Silva [5 ]
Duarte, M. Teresa [3 ]
Ferreira, Maria-Jose U. [1 ]
机构：
[1] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal
[2] ATLANTICA Escola Univ Ciencias Empresariais Saude, Fabr Polvora Barcarena, P-2730036 Oeiras, Portugal
[3] Univ Lisbon, Ctr Quim Estrutural, Inst Super Tecn, Ave Rovisco Pais, P-1049001 Lisbon, Portugal
[4] Univ Szeged, Fac Med, Dept Med Microbiol & Immunobiol, Dom Ter 10, H-6720 Szeged, Hungary
[5] Univ Pedagag, Fac Ciencias & Matemat, Ctr Estudos Mocambicanos & Etnociencias, Maputo 21402161, Mozambique
来源：
JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 08期
关键词：
ALPHA; BETA-UNSATURATED DELTA-DIKETONE; P-GLYCOPROTEIN; PHOTOCHEMICAL-REACTIONS; MEMBRANE;
D O I：
10.1021/acs.jnatprod.9b00019
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new triterpenoids, cucurbalsaminones A-C (1-3), featuring a unique 5/6/3/6/5-fused pentacyclic carbon skeleton, named cucurbalsaminane, were isolated from a methanol extract of Momordica balsamina. Their structures were elucidated by spectroscopic methods and corroborated, for 1, by structure solution using single-crystal X-ray diffraction analysis. A hypothetical biogenetic pathway for these compounds is proposed. Compounds 1-3 were evaluated for their P-glycoprotein (P-gp/ABCB1) modulation ability, using a mouse T-lymphoma MDR1-transfected cell model by the rhodamine-123 accumulation assay, and displayed potent multidrug resistance (MDR)-reversing activity.
引用
收藏
页码：2138 / 2143
页数：6
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