Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction

被引：74
|
作者：
Kim, Joa Kyum [1 ]
Kim, Young Ha [1 ]
Nam, Ho Tae [1 ]
Kim, Bum Tae [1 ]
Heo, Jung-Nyoung [1 ]
机构：
[1] Korea Res Inst Chem Technol, Ctr Med Chem, Taejon 305600, South Korea
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 16期
关键词：
D O I：
10.1021/ol801291k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki-Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formyl phenyl boronic acid, has been developed. The approach is used to efficiently produce a number of natural aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam.
引用
收藏
页码：3543 / 3546
页数：4
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